Medical Diseases

Cisplatin: Current Status and New Developments - download pdf or read online

By Archie W. Prestayko

Cisplatin: present prestige and New advancements is a set of papers provided at a symposium backed via the collage of Alabama in Birmingham finished melanoma heart and the Bristol Laboratories in Syracuse, ?ew York, and hung on September 27-28, 1979, in Atlanta, Georgia. The symposium supplied a discussion board for assessing advancements near to cisplatin as an anticancer drug, with emphasis on its scientific software in a large choice of grownup and pediatric malignancies in addition to the mechanism through which the drug seems to be to reason tumor phone dying.

Comprised of 39 chapters, this publication starts with a preclinical evaluation of cisplatin, targeting its mechanism of motion, pharmacology, antitumor job, analogs, and toxicity. The dialogue then turns to the consequences of cisplatin on DNA and the prospective relationships to cytotoxicity and mutagenicity in mammalian cells; deadly job of platinum compounds together with pyrimidine derivatives; and ultrastructural results of cisplatin. next chapters specialise in the reason of blend chemotherapy; poisonous unwanted effects of platinum analogs; radiopharmacokinetics of cisplatin; and using cisplatin for the therapy of malignancies akin to ovarian melanoma and complicated adenocarcinoma of the prostate.

This monograph should be invaluable to oncologists and pharmacologists.

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Cisplatin: Current Status and New Developments by Archie W. Prestayko

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