By Zaher A. Radi
The first thorough evaluation of cyclooxygenase inhibitors, together with their toxicity mechanisms and toxicopathological risks
Cyclooxygenases (COXs) are enzymes liable for the formation of a huge category of organic mediators known as prostanoids. Prostanoids similar to prostaglandins mediate inflammatory and anaphylactic reactions. For these being affected by irritation and ache, the pharmacological inhibition of COXs, with non-steroidal anti inflammatory medicines (NSAIDs), comparable to ibuprofen, promises aid. but using NSAIDs can set off toxicological results besides, resulting in power healthiness risks.
Comparative Pathophysiology and Toxicology of Cyclooxygenases offers a finished review of the way COX inhibitors impact quite a few physically structures, in particular the toxicity mechanisms caused whilst the COX enzyme is inhibited. The booklet presents an creation to the invention of cyclooxygenases, their use as healing brokers, in addition to an historic standpoint. laying off gentle at the ameliorations in expression, pathophysiology, and toxicology of COX inhibitors throughout species, the booklet deals a scientific exam of the results and pathophysiology of COX inhibitors and their mechanisms of toxicity, starting with the GI tract. next chapters cover:
- The pathophysiology of COX inhibition on bone, tendon, and ligament healing
- COX inhibitors and renal approach pathophysiology and mechanisms of toxicity
- The pathophysiologic position of COX inhibition within the ocular system
- COX inhibition and the respiration and cardiovascular systems
The ebook additionally sheds mild at the most up-to-date learn dedicated to constructing COX inhibitors without antagonistic side-effects. the 1st ebook to provide an intensive comparative examine the toxicological results of COX inhibitors during the physique, this worthy source can help develop the learn and improvement of more secure and greater COX drugs.
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Comparative Pathophysiology and Toxicology of Cyclooxygenases by Zaher A. Radi
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